Kidney Stones: The Video
As you know that I’ve got two-times kidney stones attack within the period of 13 years. That were very much painful; so, I hope you will not experience this kind of kidney disorder. This time, I’d love to share with you the video regarding the kidney stones.
Categories: Kidney Disease Tags: kidney stones video
Maintain Your Kidneys’ Health All the Time
My friend’s son passed away last week at the age of 25 due to renal (kidney) failure. He started undertaking dialysis a year ago. It is a showcase that dialysis is not enough to maintain your kidneys’ normal function.
I got explanation from his family that during his teenage up to his death he had unhealthy lifestyle. As a student, he accustomed to drink instant energy drink and to consume instant noodle almost everyday. As we know that both kind of modern-processed food are rich of artificial food additives, such as MSG and artificial colorings and sweeteners. I hope you could learn from this tragic case: never consume too much food containing artificial food additives.
Many people who have chronic kidney disease don’t know it, because the early signs can be very subtle. It can take many years to go from chronic kidney disease (CKD) to kidney failure. Some people with CKD live out their lives without ever reaching kidney failure.
Categories: Kidney Disease Tags: chronic kidney disease, dialysis, Food Additives, kidney failure, MSG, renal failure
Saturated Fats for the Kidney’s Health
One of the body’s most important organs is the kidney. Properly functioning kidneys are essential for maintaining proper blood volume and composition; for filtering and excreting or saving various chemical metabolites; and for helping to maintain proper blood pressure. Hypertension (high blood pressure) is known to result from improperly functioning kidneys. Research carried out during the last few years indicates that both saturated fat and cholesterol play important roles in maintaining kidney function, as do the omega-3 fatty acids.
Categories: Kidney Disease Tags: alpha-linolenic acid, cholesterol, coconut oil, DHA, EPA, fish oil-type omega-3 fatty acids, flax oil-type omega-3 fatty acid, Hypertension, immune dysfunction, kidney's health, myristic acid, omega-3 fatty acids, omega-6 oils, palmitic acid, polyunsaturated fatty acids, saturated fats, stearic acid, trans fatty acids
Recent Advances in the Pathophysiology of Nephrolithiasis
Abstract
Over the past 10 years, major progress has been made in the pathogenesis of uric acid and calcium stones. These advances have led to our further understanding of a pathogenetic link between uric acid nephrolithiasis and the metabolic syndrome, the role of Oxalobacter formigenes in calcium oxalate stone formation, oxalate transport in Slc26a6-null mice, the potential pathogenetic role of Randall’s plaque as a precursor for calcium oxalate nephrolithiasis, and the role of renal tubular crystal retention. With these advances, we may target the development of novel drugs including:
- insulin sensitizers;
- probiotic therapy with O. formigenes, recombinant enzymes, or engineered bacteria;
- treatments that involve the upregulation of intestinal luminal oxalate secretion by increasing anion transporter activity (Slc26a6), luminally active nonabsorbed agents, or oxalate binders; and
- drugs that prevent the formation of Randall’s plaque and/or renal tubular crystal adhesions.
Categories: Kidney Disease Tags: calcium oxalate stone, kidney stones, metabolic syndrome, Nephrolithiasis, Uric Acid Stone
Calcium Oxalate in Renal Stone Disease
The Terminal Metabolite That Just Won’t Go Away
Summary
The incidence of kidney stone disease, particularly calcium oxalate nephrolithiasis in the US and other countries has been increasing throughout the past three decades. Biopsy studies show that both calcium oxalate nephrolithiasis and nephrocalcinosis probably occur by different mechanisms in different subsets of patients. Before more-effective medical therapies can be developed for these conditions, we must understand the mechanisms governing the transport and excretion of oxalate and the interactions of the ion in general and renal physiology. Blood oxalate derives from diet, degradation of ascorbate, and production by the liver and erythrocytes. In mammals, oxalate is a terminal metabolite that must be excreted or sequestered. The kidneys are the primary route of excretion and the site of oxalate’s only known function. Oxalate stimulates the uptake of chloride, water, and sodium by the proximal tubule through the exchange of oxalate for sulfate or chloride via the solute carrier SLC26A6. Fecal excretion of oxalate is stimulated by hyperoxalemia in rodents, but no similar phenomenon has been observed in humans. Studies in which rats were treated with C-oxalate have shown that less than 2% of a chronic oxalate load accumulates in the internal organs, plasma, and skeleton. These studies have also demonstrated that there is interindividual variability in the accumulation of oxalate, especially by the kidney. This Review summarizes the transport and function of oxalate in mammalian physiology and the ion’s potential roles in nephrolithiasis and nephrocalcinosis.